Promoter hypermethylation of tumor-related genes in peritoneal lavage and the prognosis of patients with colorectal cancer.

@article{Kamiyama2009PromoterHO,
  title={Promoter hypermethylation of tumor-related genes in peritoneal lavage and the prognosis of patients with colorectal cancer.},
  author={Hidenori Kamiyama and Hiroshi Noda and Osamu Takata and Koichi Suzuki and Yutaka J. Kawamura and Fumio Konishi},
  journal={Journal of surgical oncology},
  year={2009},
  volume={100 1},
  pages={69-74}
}
BACKGROUND AND OBJECTIVES The predictive value of free cancer cells in the peritoneal fluid of patients with colorectal cancer (CRC) remain to be elucidated. The aim of this study was to determine the prognostic relevance of the methylation of tumor-related genes detected in the peritoneal lavage fluid (PLF) of patients undergoing a resection for CRC. METHODS The promoter methylation pattern of four target genes, CDH1, CDKN2A (p16), MGMT, and APC, was examined in 51 primary CRC and… CONTINUE READING

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