Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.

@article{Yamada2006PromoterHO,
  title={Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.},
  author={Daisuke Yamada and Shinji Kikuchi and Yuko N Williams and Mika Sakurai-Yageta and Mari Masuda and Tomoko Maruyama and Kyoichi Tomita and David H Gutmann and Tadao Kakizoe and Tadaichi Kitamura and Yae Kanai and Yoshinori Murakami},
  journal={International journal of cancer},
  year={2006},
  volume={118 4},
  pages={916-23}
}
Renal clear cell carcinoma (RCCC) is a malignant tumor with poor prognosis caused by the high incidence of metastasis to distal organs. Although metastatic RCCC cells frequently show aberrant cytoskeletal organization, the underlying mechanism has not been elucidated. DAL-1/4.1B is an actin-binding protein implicated in the cytoskeleton-associated processes, while its inactivation is frequently observed in lung and breast cancers and meningiomas, suggesting that 4.1B is a potential tumor… CONTINUE READING