Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis.

@article{Wu2006PromoterHO,
  title={Promoter hypermethylation of progesterone receptor isoform B (PR-B) in endometriosis.},
  author={Yan Wu and Estil Strawn and Zainab Basir and Gloria Halverson and Sun-wei Guo},
  journal={Epigenetics},
  year={2006},
  volume={1 2},
  pages={106-11}
}
The physiological effects of progesterone (P) are mediated by two isoforms of progesterone receptors (PRs): PR-A and PR-B. Progestins have long been used in the treatment of endometriosis but unfortunately the relief of pain is relatively short-term. In addition, about nine percent of women with endometriosis simply do not respond to progestin therapy due to unknown reasons. In fact, a general tendency for relative progesterone resistance within eutopic and ectopic endometrium of women with… CONTINUE READING
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