Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions.

@article{Zou2009PromoterHO,
  title={Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions.},
  author={Xiaoping Zou and Bin Zhang and Xiao-qi Zhang and Min Chen and Jun Cao and Wen-jia Liu},
  journal={Human pathology},
  year={2009},
  volume={40 11},
  pages={
          1534-42
        }
}
Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. To date, several reports on methylation of various genes in gastric cancer have been published. However, most of these studies have focused on cancer tissues or only a single gene. In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin… CONTINUE READING
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