Promoter hypermethylation of multiple genes in gastric lymphoma.

  title={Promoter hypermethylation of multiple genes in gastric lymphoma.},
  author={Qin Huang and Xiaobo Su and Lingbao Ai and Michelle Li and Chung-Yang Fan and Lawrence M. Weiss},
  journal={Leukemia & lymphoma},
  volume={48 10},
Aberrant hypermethylation of CpG islands in the promoter region of tumor suppressor and other important genes in neoplastic cells of lymphoma has been demonstrated to be one of the mechanisms for epigenetic loss of gene function. In this study, we analyzed promoter hypermethylation of the following genes in 49 cases of primary gastric lymphoma (PGL): ATM, p16INK4a(CDKN2A), hMLH1, MGMT, DAPK, and CDH1(ECAD). The PGL cases studied included 26 (53%) cases of diffuse large B-cell lymphoma (DLBCL… CONTINUE READING


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