Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma.

  title={Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma.},
  author={Naohide Oue and Hideo Shigeishi and Hiroki Kuniyasu and Hiroshi Yokozaki and Kazuya Kuraoka and Reiko Ito and Wataru Yasui},
  journal={International journal of cancer},
  volume={93 6},
Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes in neoplasms. Recently, O(6)-methylguanine-DNA methyltransferase, MGMT, was shown to be hypermethylated in certain carcinomas, resulting in loss of MGMT protein. We studied DNA methylation of CpG islands of the MGMT gene by methylation specific PCR in 26 gastric carcinoma tissues and 8 gastric carcinoma cell lines for comparison with levels of MGMT… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 45 extracted citations

Epigenetic changes of DNA repair genes in cancer.

Journal of molecular cell biology • 2011
View 4 Excerpts
Highly Influenced

MGMT methylation assessment in glioblastoma: MS-MLPA versus human methylation 450K beadchip array and immunohistochemistry.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico • 2016

Similar Papers

Loading similar papers…