Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer.

@article{Narayan2004PromoterHO,
  title={Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer.},
  author={Gopeshwar Narayan and H Arias-Pulido and Subhadra V. Nandula and Katia Basso and Dorcas Deborah Sugirtharaj and Hernan Vargas and Mahesh M. Mansukhani and Jeannine A Villella and Larissa Meyer and Achim Schneider and Lutz Gissmann and Matthias D{\"u}rst and Bhavana Pothuri and V. V. S. Murty},
  journal={Cancer research},
  year={2004},
  volume={64 9},
  pages={2994-7}
}
Patients with advanced stage invasive cervical cancer (CC) exhibit highly complex genomic alterations and respond poorly to conventional treatment protocols. In our efforts to understand the molecular genetic basis of CC, we examined the role of Fanconi Anemia (FA)-BRCA pathway. Here, we show that FANCF gene is disrupted by either promoter hypermethylation and/or deregulated gene expression in a majority of CC. Inhibition of DNA methylation and histone deacetylases induces FANCF gene re… CONTINUE READING

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