Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer.

@article{Liu2009PromoterHM,
  title={Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer.},
  author={Xin Liu and Emily Kai Yee Lam and Xian Wang and Jianbin Zhang and Yuen Yee Cheng and Yun Wah Lam and Enders Kai On Ng and Jun Yu and Francis Ka-leung Chan and Hong Chuan Jin and Joseph Jao Yiu Sung},
  journal={Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine},
  year={2009},
  volume={30 5-6},
  pages={242-8}
}
As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 23 references

ulin 1 is downregulated through promoter hypermethylation in gastric cancer

  • H Jin, X Wang, +10 authors Q Tao
  • Br J Cancer
  • 2008

The epigenomics of can

  • KF To, WK Leung, +6 authors JJ Sung
  • Cell
  • 2007

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