Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.

@article{Jiang2006PromoterHD,
  title={Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.},
  author={Zheng Jiang and Xingang Li and Jin Hu and Wei Zhou and Yuquan Jiang and Gang Li and Daru Lu},
  journal={Neuroscience research},
  year={2006},
  volume={56 4},
  pages={450-8}
}
LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but their methylation statuses are still unknown in human astrocytoma. Here, we found that the promoter hypermethylation frequencies of LATS1 and LATS1 were 63.66% (56/88) and 71.5% (63/88) in 88 astrocytomas by methylation-specific PCR. But no methylation of LATS1 and LATS2 promoter was detected in the 10 normal brain tissues. There was an increased methylation frequency of LATS1 and LATS2 with the malignant… CONTINUE READING