Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk.

@article{Lewis2005PromoterHI,
  title={Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk.},
  author={Cheryl M. Lewis and Leslie R Cler and Da-Wei Bu and Sabine Zoechbauer-Mueller and Sara Milchgrub and Elizabeth Z Naftalis and A. Marilyn Leitch and John D. Minna and David Michael Euhus},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 1},
  pages={166-72}
}
INTRODUCTION The tumor suppressor genes RASSF1A, APC, H-cadherin, RARbeta2, and cyclin D2 are methylated more frequently in breast cancer than in adjacent benign tissue. However, it is unclear whether promoter methylation of tumor suppressor genes in benign breast tissue is associated with an increased risk for breast cancer. METHODS Promoter hypermethylation was measured in benign and malignant breast samples obtained by fine needle aspiration biopsy from 27 breast cancer patients and 55… CONTINUE READING
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