Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from China

@article{Huang2004PromoterHA,
  title={Promoter hypermethylation and protein expression of the p16 gene: analysis of 43 cases of B-cell primary gastric lymphomas from China},
  author={Qin Huang and Lingbao Ai and Zackery Y Zhang and Chun-Yang Fan and Lawrence M. Weiss},
  journal={Modern Pathology},
  year={2004},
  volume={17},
  pages={416-422}
}
The p16 (CDKN2a/INK4a) gene is an important tumor-suppressor gene, involved in the p16/cyclin-dependent kinase/retinoblastoma gene pathway of cell cycle control. The p16 protein is considered to be a negative regulator of the pathway. Promoter hypermethylation resulting in inactivation of the p16 gene has been found in various hematopoietic malignancies, including non-Hodgkin's lymphoma, and may play a role in transformation/clinical aggressiveness of those tumors. However, the p16 protein… CONTINUE READING

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