Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer.

@article{Rehman2005PromoterHO,
  title={Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer.},
  author={Ishtiaq Rehman and Simon S. Cross and James W. Catto and Aaron Leiblich and Abir Lal Mukherjee and A. -R. Azzouzi and Hing Y Leung and Freddie Hamdy},
  journal={The Prostate},
  year={2005},
  volume={65 4},
  pages={322-30}
}
BACKGROUND S100A6 and S100A2 are members of the S100 family of calcium binding proteins, which are down regulated in prostate cancer, however the molecular mechanism(s) underlying their loss of expression is unknown. METHODS The promoter and exon 1 region of the S100A6 and S100A2 genes was sequenced in bisulfite modified DNA from non-malignant, benign prostatic hyperplasia (BPH), malignant and metastatic prostate tissues and in cell lines. Immunohistochemistry was performed to correlate… CONTINUE READING

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