Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites

@inproceedings{Montesion2018PromoterEO,
  title={Promoter expression of HERV-K (HML-2) provirus-derived sequences is related to LTR sequence variation and polymorphic transcription factor binding sites},
  author={Meagan Montesion and Zachary H Williams and Ravi P Subramanian and Charlotte Kuperwasser and John M Coffin},
  booktitle={Retrovirology},
  year={2018}
}
Increased transcription of the human endogenous retrovirus group HERV-K (HML-2) is often seen during disease. Although the mechanism of its tissue-specific activation is unclear, research shows that LTR CpG hypomethylation alone is not sufficient to induce its promoter activity and that the transcriptional milieu of a malignant cell contributes, at least partly, to differential HML-2 expression. We analyzed the relationship between LTR sequence variation and promoter expression patterns in… CONTINUE READING
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