Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia.

@article{Watt2000PromoterDA,
  title={Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia.},
  author={Paul M. Watt and R. Amar Kumar and Ursula R. Kees},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={29 4},
  pages={371-7}
}
Despite considerable work on the epigenetic control of tumor suppressor genes, little is known about the potential role of promoter CpG demethylation in the activation of oncogenes in lymphoid tumors. The HOX11 proto-oncogene is frequently activated in T-cell acute lymphoblastic leukemia (T-ALL). HOX11 activation can occur in the absence of translocation of the gene to the T-cell receptor locus (Salvati et al., 1995), implying that activation mechanisms must be involved other than the… CONTINUE READING