Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1.

@article{Melchior2002PromoterCA,
  title={Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1.},
  author={Chantal Melchior and Stephanie Kreis and Bassam Janji and Nelly Kieffer},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1575 1-3},
  pages={117-22}
}
Integrin-linked kinase (ILK)-1 is a 59-kDa serine-threonine protein kinase, which associates with the cytoplasmic domain of beta 1, beta 2 and beta 3 integrins and acts as a receptor proximal kinase regulating integrin-mediated signal transduction. We have recently identified an isoform of ILK (ILK-2), which is expressed, in a TGF-beta 1-dependent manner, in a highly invasive tumor cell line but not in normal adult tissues. In contrast, ILK-1 is ubiquitously expressed in normal tissues and is… CONTINUE READING