Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene.

@article{BaileyDell2001PromoterCA,
  title={Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene.},
  author={Kimberly J. Bailey-Dell and Bret Hassel and Laurence A. Doyle and Douglas D. Ross},
  journal={Biochimica et biophysica acta},
  year={2001},
  volume={1520 3},
  pages={234-41}
}
The breast cancer resistance protein (BCRP) gene, formally known as ATP-binding cassette transporter G2 (ABCG2) gene, encodes an ABC half transporter that causes resistance to certain cancer chemotherapeutic drugs when transfected and expressed in drug sensitive cancer cells. Here we report the organization of the BCRP gene, and the initial characterization of the BCRP promoter. We identified the genomic sequence of BCRP and its promoter by screening a human genomic lambda phage library, as… CONTINUE READING