Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

  title={Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control},
  author={Isaia Barbieri and Konstantinos Tzelepis and Luca Pandolfini and Junwei Shi and Gonzalo Mill{\'a}n-Zambrano and Samuel C. Robson and Demetrios Aspris and Valentina Migliori and Andrew J. Bannister and Namshik Han and Etienne De Braekeleer and Hannes Ponstingl and Alan G Hendrick and Christopher R Vakoc and George S Vassiliou and Tony Kouzarides},
N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding and non-coding RNAs that is catalysed by the METTL3–METTL14 methyltransferase complex. However, the specific role of these enzymes in cancer is still largely unknown. Here we define a pathway that is specific for METTL3 and is implicated in the maintenance of a leukaemic state. We identify METTL3 as an essential gene for growth of acute myeloid leukaemia cells in two distinct genetic screens. Downregulation of… CONTINUE READING
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