Promoter analysis of the human alpha1,3/4-fucosyltransferase gene (FUT III).

@article{Dbrowska2005PromoterAO,
  title={Promoter analysis of the human alpha1,3/4-fucosyltransferase gene (FUT III).},
  author={Anna Dąbrowska and Dagmara Baczyńska and Katarzyna Widerak and Anna Katarzyna Laskowska and Maciej Ugorski},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1731 1},
  pages={66-73}
}
alpha1,3/4-Fucosyltransferase (FUT3) is involved in the synthesis of sialyl Le(a) tetrasaccharide, a tumor-associated carbohydrate antigen. Fucosyltransferases are thought to be important regulatory enzymes in the synthesis of fucosylated structures. However, there are conflicting data on the role of FUT3 in the synthesis of this carbohydrate structure and more studies on the regulation of FUT III gene expression are needed. Therefore, as first step, the promoter of FUT III gene was cloned and… CONTINUE READING

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