Promoter analysis of human CC chemokine CCL23 gene in U937 monocytoid cells.

@article{Shin2007PromoterAO,
  title={Promoter analysis of human CC chemokine CCL23 gene in U937 monocytoid cells.},
  author={Yong-Hyun Shin and Guy Wilhem Lee and Kyung-No Son and Sang Min Lee and Chang Joong Kang and Byoung S. Kwon and Jiyoung Kim},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1769 3},
  pages={204-8}
}
Expression of CCL23 is induced by external stimuli including PMA in monocytes, but its transcriptional regulation has not been studied to date. Serial deletion analysis of its 5' flanking region revealed that the region -293 to +31 was important for induction by PMA. Cis-acting elements at the -269/-264 (NFAT site), -167/-159 (NF-kappaB site), and -51/-43 (AP-1 site) positions were identified as the critical sites for the CCL23 expression in U937 cells. We demonstrated the binding of the… CONTINUE READING

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