Promoter Proximal Sequences Modulate RNA Polymerase II Elongation by a Novel Mechanism

@article{Reeder1996PromoterPS,
  title={Promoter Proximal Sequences Modulate RNA Polymerase II Elongation by a Novel Mechanism},
  author={Thadd C Reeder and Diane K. Hawley},
  journal={Cell},
  year={1996},
  volume={87},
  pages={767-777}
}
The adenovirus major late arrest site blocks transcription by mammalian RNA polymerase II in vitro downstream of the major late promoter but not the mouse beta-globin promoter. We localized the sequences responsible for anti-arrest to the 5' end of the beta-globin transcript and demonstrated that anti-arrest required that this region of RNA form base pairs with the nascent transcript upstream of the arrest site. Small antisense RNA or DNA oligonucleotides hybridizing upstream of the arrest site… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Mechanistic studies transcription termination by purified RNA polymerase II . Biochemisof transcription arrest at the adenovirus major late attenuation site . try 29 , 269 – 278

D. K. Wiest, D. Wang, D. K. Hawley
Analysis of the signals for • 1992
View 7 Excerpts
Highly Influenced

Increased accommodation and monkey cells for the ability to attenuate transcripts that beginof nascent RNA in a product site on RNApolymerase II during arrest . at the adenovirus major late promoter

M. Wind, D. Reines
J . Virol . Proc . Natl . Acad . Sci . USA • 1996

Protein-RNA interactions in the active center of transcription elongation complex.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 1 Excerpt

Cou - pling between transcription termination and RNA polymerase inchworming

E. Nudler, M. Kashlev, V. Nikiforov, A. Goldfarb
Cell • 1995
View 2 Excerpts

Identification of a decay in transcripelongation

D. Reines
1995
View 2 Excerpts

The RNA polymerase II elongation complex.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 1995

Similar Papers

Loading similar papers…