Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome

@article{Deckers2015PromoterMO,
  title={Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome},
  author={I. Deckers and L. Schouten and L. van Neste and I. J. van Vlodrop and P. Soetekouw and M. Baldewijns and Jana Jeschke and N. Ahuja and J. Herman and P. A. van den Brandt and M. van Engeland},
  journal={Clinical Cancer Research},
  year={2015},
  volume={21},
  pages={3492 - 3500}
}
Purpose: In this era of molecular diagnostics, prediction of clear-cell renal cell cancer (ccRCC) survival requires optimization, as current prognostic markers fail to determine individual patient outcome. Epigenetic events are promising molecular markers. Promoter CpG island methylation of cysteine dioxygenase type 1 (CDO1), which was identified as prognostic marker for breast cancer, is studied as a potential marker for ccRCC survival. Experimental Design: We collected primary tissues of 365… Expand
Promoter DNA methylation of CDO1 gene and its clinical significance in esophageal squamous cell carcinoma.
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