Promoter Hypermethylation of Estrogen Receptor Alpha Gene Is Correlated to Estrogen Receptor Negativity in Iranian Patients with Sporadic Breast Cancer

@inproceedings{Izadi2012PromoterHO,
  title={Promoter Hypermethylation of Estrogen Receptor Alpha Gene Is Correlated to Estrogen Receptor Negativity in Iranian Patients with Sporadic Breast Cancer},
  author={Pantea Izadi and Mehrdad Noruzinia and Morteza Karimipoor and Mohammad Hamid Karbassian and Mohamad Akbari},
  booktitle={Cell journal},
  year={2012}
}
OBJECTIVE Breast Cancer is the most common cancer in Iranian women. Breast tumors are classified based on the estrogen receptor alpha (ERα) expression status into ER negative and ER positive tumors. ER negative tumors tend to have worse prognosis and less likely to respond to endocrine therapy. Aberrant methylation of gene promoter is one of the mechanisms… CONTINUE READING