Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.

Abstract

The G-quadruplex, a non-B DNA motif that forms in certain G-rich sequences, is often located near transcription start sites in growth regulatory genes. Multiple lines of evidence show that reactive oxygen species generated as second messengers during physiologic signaling target specific DNA sequences for oxidative base modifications. Because guanine… (More)
DOI: 10.1016/j.freeradbiomed.2012.04.024

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Cite this paper

@article{Clark2012PromoterGS, title={Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.}, author={D. Clark and Tzu L. Phang and Michael G. Edwards and Mark W. Geraci and Mark N. Gillespie}, journal={Free radical biology & medicine}, year={2012}, volume={53 1}, pages={51-9} }