Promoter Function of the Angiogenic Inducer Cyr61 Gene in Transgenic Mice: Tissue Specificity, Inducibility During Wound Healing, and Role of the Serum Response Element*

@inproceedings{Latinki2001PromoterFO,
  title={Promoter Function of the Angiogenic Inducer Cyr61 Gene in Transgenic Mice: Tissue Specificity, Inducibility During Wound Healing, and Role of the Serum Response Element*},
  author={Branko V. Latinki{\'c} and Fan-E Mo and Jeffrey A. Greenspan and Neal G. Copeland and Debra J. Gilbert and Nancy A. Jenkins and Susan R. Ross and Lester F. Lau},
  year={2001}
}
The cysteine-rich angiogenic protein 61 (Cyr61) is an extracellular matrix-associated, heparin-binding protein that mediates cell adhesion, stimulates cell migration, and enhances growth factor-induced cell proliferation. Cyr61 also promotes chondrogenic differentiation and induces neovascularization. In this study, we show that a 2-kb fragment of the Cyr61 promoter, which confers growth factor-inducible expression in cultured fibroblasts, is able to drive accurate expression of the reporter… CONTINUE READING

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