Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer.

@article{Deckers2017PromoterCI,
  title={Promoter CpG island methylation in ion transport mechanisms and associated dietary intakes jointly influence the risk of clear-cell renal cell cancer.},
  author={I. Deckers and M. van Engeland and P. A. van den Brandt and L. van Neste and P. Soetekouw and M. Aarts and M. Baldewijns and A. Keszei and L. Schouten},
  journal={International journal of epidemiology},
  year={2017},
  volume={46 2},
  pages={
          622-631
        }
}
Background Sodium intake, but not potassium or fluid intake, has been associated with higher renal cell cancer (RCC) risk. However, risk factors may differ by molecular subtypes of the tumour. In renal physiology, electrolyte and water homeostasis is facilitated by ion transport mechanisms (ITM). Aberrant regulation of ITM genes, for example by promoter CpG island methylation, may modify associations between sodium, potassium and fluid intake and RCC risk. Methods We identified ARHGDIG… Expand
Identification of methylation‐driven genes related to prognosis in clear‐cell renal cell carcinoma
A DNA methylation signature to improve survival prediction of gastric cancer
Sodium reduction in South Korean restaurants: A Daegu-based intervention project.

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