Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.

@article{Derks2009PromoterCI,
  title={Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.},
  author={Sarah Derks and Linda J. W. Bosch and Hanneke E. C. Niessen and Peter T. M. Moerkerk and Sandra M. van den Bosch and Beatriz Carvalho and Sandra Mongera and Jan Willem Voncken and G A Meijer and Adriaan P. de Bru{\"i}ne and James G. Herman and Manon van Engeland},
  journal={Carcinogenesis},
  year={2009},
  volume={30 6},
  pages={1041-8}
}
Chromosomal loss of 18q21 is a frequent event in colorectal cancer (CRC) development, suggesting that this region harbors tumor suppressor genes (TSGs). Several candidate TSGs, among which methyl-CpG-binding domain protein 1 (MBD1), CpG-binding protein CXXC1, Sma- and Mad-related protein 4 (SMAD4), deleted in colon cancer (DCC) and methyl-CpG-binding domain protein 2 (MBD2) are closely linked on a 4-Mb DNA region on chromosome18q21. As TSGs can be epigenetically silenced, this study… CONTINUE READING
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