Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells.

@article{Hua2011PromotedCG,
  title={Promoted cancer growth by stimulating cell proliferation and decreasing apoptosis using a lentivirus-based EphB2 RNAi in pancreatic carcinoma CFPAC-1 cells.},
  author={Yong-qiang Hua and Hua-qiang Ouyang and Zhen Chen and Zhi-qiang Meng and Jian-min Luo and Jun-hua Lin and Zhenhua Zhou and Hao Chen and Kun Wang and Lu-ming Liu},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2011},
  volume={65 2},
  pages={123-31}
}
Several studies have reported the change of EphB2 in a variety of carcinomas and suggested a functional relation between EphB2 and tumor progression. However, its role in human pancreatic carcinoma has not been described. The aim of this study was to evaluate the significance of EphB2 in human pancreatic carcinoma CFPAC-1 cells. A lentivirus-based RNA interference (RNAi) vector was designed, synthesized and transfected into CFPAC-1 cells to inhibit EphB2 expression. WST-8 based Colorimetric… CONTINUE READING
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