Promising therapeutic targets in neuroblastoma.

  title={Promising therapeutic targets in neuroblastoma.},
  author={Katherine K. Matthay and Rani E. George and Alice Yu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={18 10},
Neuroblastoma, the most common extracranial solid tumor in children, is derived from neural crest cells. Nearly half of patients present with metastatic disease and have a 5-year event-free survival of <50%. New approaches with targeted therapy may improve efficacy without increased toxicity. In this review we evaluate 3 promising targeted therapies: (i) (131)I-metaiodobenzylguanidine (MIBG), a radiopharmaceutical that is taken up by human norepinephrine transporter (hNET), which is expressed… CONTINUE READING