Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide.

@article{Bhattacharya2002PromisingRO,
  title={Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide.},
  author={Rahul Bhattacharya and R. C. Vijayaraghavan},
  journal={Human & experimental toxicology},
  year={2002},
  volume={21 6},
  pages={297-303}
}
Treatment of cyanide poisoning generally includes amyl nitrite and/or sodium nitrite (SN) in combination with sodium thiosulphate (STS). However, in many instances of cyanide poisoning, use of nitrites is contraindicated due to their strong vasoactive properties. alpha-Ketoglutarate (alpha-KG) antagonizes cyanide poisoning by cyanohydrin formation. Protective efficacy of graded doses of alpha-KG (p.o.) as pretreatment, simultaneous treatment or post-treatment was evaluated against acute… CONTINUE READING