Promising Role of ANGPTL4 Gene in Diabetic Wound Healing

@article{Arya2014PromisingRO,
  title={Promising Role of ANGPTL4 Gene in Diabetic Wound Healing},
  author={Awadhesh Kumar Arya and Kamlakar Tripathi and Parimal Das},
  journal={The International Journal of Lower Extremity Wounds},
  year={2014},
  volume={13},
  pages={58 - 63}
}
Diabetes mellitus (DM) is one of the severe metabolic disorders of carbohydrate metabolism worldwide. Developing countries are at higher risk of DM, and there is significant evidence that it is epidemic in many economically developing and newly industrialized countries. Among all other complications associated with DM, delayed wound healing is a major concern in diabetic patients. Wound healing is a natural healing process that starts immediately after injury. This involves interaction of a… 
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TLDR
The hypothesis that the oxidative stress, apoptosis, connexins and other molecules involved in the regulation of chronic wound healing in diabetes mellitus is supported and proper understanding of the mechanisms controlling apoptosis and tissue repair during diabetes is given and may eventually develop therapeutic modalities to fasten the healing process in diabetic patients.
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New links between plasma treatment of cells and tissues, and the perception and intracellular translation of plasma-derived reactive species via redox signaling pathways are discussed, which reanimates the idea of redox repair in physiological healing.
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TLDR
Immediate action on changes in the standard clinical treatment may be taken following poor response of ulcer healing progress to prevent further deterioration of wounds, which may lead to foot amputation.
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The potential miR-340-3p-DTX3L interaction that has been systematically validated in miRNA prediction databases was proposed to participate in the disrupted skin homeostasis, altering the defense and immune response of diabetic skin.
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Specialised ONS can be a therapeutic option for hard-to-heal wounds and did not induce changes in blood pressure, blood glucose level or renal function, according to the literature.
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