Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies.

@article{Scalise2016PromisingEO,
  title={Promising Efficacy of Benznidazole Nanoparticles in Acute Trypanosoma cruzi Murine Model: In-Vitro and In-Vivo Studies.},
  author={M. Scalise and E. Arr{\'u}a and M. S. Rial and M. Esteva and C. Salomon and L. Fichera},
  journal={The American journal of tropical medicine and hygiene},
  year={2016},
  volume={95 2},
  pages={
          388-93
        }
}
The aim of this study was to evaluate the effectiveness of benznidazole nanoparticles (BNZ-nps) on trypomastigote forms and on intracellular infection in mammalian cells and primary cardiac myocyte cells. Its effectiveness was also evaluated on acute Trypanosoma cruzi Nicaragua mice infection. Trypomastigotes from culture were treated with different concentrations of BNZ-nps to determine the drug concentration that lyses 50% of trypomastigotes (LC50). Infected mammalian cells were incubated… Expand
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