Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences.

@article{Kumar2016PromisesOA,
  title={Promises of a biocompatible nanocarrier in improved brain delivery of quercetin: Biochemical, pharmacokinetic and biodistribution evidences.},
  author={Pramod Kumar and Gajanand Sharma and Rajendra Kumar and Bhupinder Singh and Ruchi Malik and O P Katare and Kaisar Raza},
  journal={International journal of pharmaceutics},
  year={2016},
  volume={515 1-2},
  pages={307-314}
}
In various neurological disorders, antioxidants are frequently prescribed along with the specific treatment modalities. One such promising natural flavonoid is quercetin, offering better outcomes than established vitamins E and C. Though with immense promises, various challenges like poor oral-bioavailability (<2%), extensive first-pass metabolism, poor brain permeability, hydrophobic nature and physiological pH instability hinder its proper usage. Hence, it was planned to prepare quercetin… CONTINUE READING