Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen.

@article{Pier2003PromisesAP,
  title={Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen.},
  author={Gerald B Pier},
  journal={Carbohydrate research},
  year={2003},
  volume={338 23},
  pages={2549-56}
}
Antibodies directed to the Pseudomonas aeruginosa lipopolysaccharide (LPS) O-antigens have clearly shown to mediate the most effective immunity to infection caused by LPS-smooth strains. Such strains are major causes of disease in immunocompromised hosts such as burn or cancer patients, individuals in intensive care units, and those who utilize extended-wear contact lenses. Yet producing an effective vaccine composed of non-toxic, immunogenic polysaccharides has been challenging. The chemical… CONTINUE READING