Promise and pitfalls of g-ratio estimation with MRI

@article{Campbell2018PromiseAP,
  title={Promise and pitfalls of g-ratio estimation with MRI},
  author={Jennifer S. W. Campbell and Ilana R Leppert and Sridar Narayanan and Mathieu Boudreau and Tanguy Duval and Julien Cohen-Adad and Gilbert Bruce Pike and Nikola Stikov},
  journal={NeuroImage},
  year={2018},
  volume={182},
  pages={80-96}
}
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82 Citations
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82 Citations

Whole brain g-ratio mapping using myelin water imaging (MWI) and neurite orientation dispersion and density imaging (NODDI)
Age‐related estimates of aggregate g‐ratio of white matter structures assessed using quantitative magnetic resonance neuroimaging
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A quadratic, U‐shaped, relationship between aggregate g‐ratio and age is found in most cerebral regions investigated, suggesting myelin maturation until middle age followed by a decrease at older ages.
Cerebral aggregate g-ratio mapping using magnetic resonance relaxometry and diffusion tensor imaging to investigate sex and age-related differences in white matter microstructure.
The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging
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The efficiency of a data-driven B1+ correction approach that was applied retrospectively without additional reference measurements found that it reduced the bias and error in the MR g-ratio by a factor of three.
Modelling conduction delays in the corpus callosum using MRI-measured g-ratio
TLDR
A novel framework in which the structural properties of fibers are incorporated in a biophysical model of axon conduction, to predict conduction delays of long-range white matter fibers is presented, and conduction delay estimates that are compatible with values generated more directly are found.
Introducing axonal myelination in connectomics: A preliminary analysis of g-ratio distribution in healthy subjects
Experimental studies of g-ratio MRI in ex vivo mouse brain
Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume
TLDR
The imaging g-ratio may serve as a biomarker for the relative degree of axonal and myelin loss in MS.
Validation strategies for the interpretation of microstructure imaging using diffusion MRI
Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio
TLDR
The myelin of WM was more damaged than axons in plaques and periplaque WM of patients with MS, and myelin and axon volume fractions and g-ratio may potentially be useful for evaluating WM damage in Patients with MS.
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References

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Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio
TLDR
The myelin of WM was more damaged than axons in plaques and periplaque WM of patients with MS, and myelin and axon volume fractions and g-ratio may potentially be useful for evaluating WM damage in Patients with MS.
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