Promise and pitfalls of g-ratio estimation with MRI

@article{Campbell2018PromiseAP,
  title={Promise and pitfalls of g-ratio estimation with MRI},
  author={Jennifer S. W. Campbell and Ilana R Leppert and Sridar Narayanan and Mathieu Boudreau and Tanguy Duval and Julien Cohen-Adad and Gilbert Bruce Pike and Nikola Stikov},
  journal={NeuroImage},
  year={2018},
  volume={182},
  pages={80-96}
}
Age‐related estimates of aggregate g‐ratio of white matter structures assessed using quantitative magnetic resonance neuroimaging
TLDR
A quadratic, U‐shaped, relationship between aggregate g‐ratio and age is found in most cerebral regions investigated, suggesting myelin maturation until middle age followed by a decrease at older ages.
The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging
TLDR
The efficiency of a data-driven B1+ correction approach that was applied retrospectively without additional reference measurements found that it reduced the bias and error in the MR g-ratio by a factor of three.
Modelling conduction delays in the corpus callosum using MRI-measured g-ratio
TLDR
A novel framework in which the structural properties of fibers are incorporated in a biophysical model of axon conduction, to predict conduction delays of long-range white matter fibers is presented, and conduction delay estimates that are compatible with values generated more directly are found.
Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume
TLDR
The imaging g-ratio may serve as a biomarker for the relative degree of axonal and myelin loss in MS.
Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio
TLDR
The myelin of WM was more damaged than axons in plaques and periplaque WM of patients with MS, and myelin and axon volume fractions and g-ratio may potentially be useful for evaluating WM damage in Patients with MS.
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