Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle

@inproceedings{Welte2012PromiscuousTO,
  title={Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle},
  author={Thomas Welte and Renuka Kudva and Patrick Kuhn and Lukas Sturm and David Braig and Matthias M{\"u}ller and Bettina Warscheid and Friedel Drepper and Hans-Georg Koch},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Protein insertion into the bacterial inner membrane is facilitated by SecYEG or YidC. Although SecYEG most likely constitutes the major integration site, small membrane proteins have been shown to integrate via YidC. We show that YidC can also integrate multispanning membrane proteins such as mannitol permease or TatC, which had been considered to be exclusively integrated by SecYEG. Only SecA-dependent multispanning membrane proteins strictly require SecYEG for integration, which suggests that… CONTINUE READING
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