Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.

@article{Gbler2007PromiscuousGE,
  title={Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.},
  author={Jana G{\"a}bler and Janna Arnold and Bruno Kyewski},
  journal={European journal of immunology},
  year={2007},
  volume={37 12},
  pages={
          3363-72
        }
}
Thymic epithelial cells (TEC) form the structural and functional microenvironment necessary for the establishment and quality control of the T cell repertoire. In addition, they provide an ectopic source of numerous tissue-restricted antigens (TRA), a feature called promiscuous gene expression (pGE). How the regulation of pGE is related to the cell biology of TEC subset(s), e.g. their turnover and developmental interrelationship is still poorly understood. The observation that pGE is foremost a… CONTINUE READING

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