Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa.

@article{Minelli2008PromiscuousCA,
  title={Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1/2 in the adenosine A1 receptor signalling in mammalian spermatozoa.},
  author={Alba Minelli and Ilaria Bellezza and Giulia Collodel and Bertil B. Fredholm},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 4},
  pages={
          931-41
        }
}
Mammalian spermatozoa require a maturational event after ejaculation that allows them to acquire the capacity for fertilisation. This process occurs spontaneously during the transit through the female reproductive tract where spermatozoa are in contact with micromolar concentrations of adenosine that might act as a capacitative effector. This study shows that the adenosine A1 receptor agonist, 2-chloro-N6-cyclopentyladenosine, can induce capacitation, i.e., the ability to undergo the acrosome… CONTINUE READING

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