Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

Abstract

The Hsp70 chaperone system is integrated into a myriad of biochemical processes that are critical for cellular proteostasis. Although detailed pictures of Hsp70 bound with peptides have emerged, correspondingly detailed structural information on complexes with folding-competent substrates remains lacking. Here we report a methyl-TROSY based solution NMR… (More)
DOI: 10.7554/eLife.28030

Topics

8 Figures and Tables

Cite this paper

@inproceedings{Rosenzweig2017PromiscuousBB, title={Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles}, author={R. F. Rosenzweig and Ashok Sekhar and Jayashree Nagesh and Tairan Yuwen}, booktitle={eLife}, year={2017} }