Promiscuous activity of (S,S)-butanediol dehydrogenase is responsible for glycerol production from 1,3-dihydroxyacetone in Corynebacterium glutamicum under oxygen-deprived conditions

@article{Jojima2014PromiscuousAO,
  title={Promiscuous activity of (S,S)-butanediol dehydrogenase is responsible for glycerol production from 1,3-dihydroxyacetone in Corynebacterium glutamicum under oxygen-deprived conditions},
  author={T. Jojima and Takafumi Igari and Yasuhiro Moteki and Masako Suda and H. Yukawa and M. Inui},
  journal={Applied Microbiology and Biotechnology},
  year={2014},
  volume={99},
  pages={1427-1433}
}
  • T. Jojima, Takafumi Igari, +3 authors M. Inui
  • Published 2014
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
  • Corynebacterium glutamicum can consume glucose to excrete glycerol under oxygen deprivation. Although glycerol synthesis from 1,3-dihydroxyacetone (DHA) has been speculated, no direct evidence has yet been provided in C. glutamicum. Enzymatic and genetic investigations here indicate that the glycerol is largely produced from DHA and, unexpectedly, the reaction is catalyzed by (S,S)-butanediol dehydrogenase (ButA) that inherently catalyzes the interconversion between S-acetoin and (S,S)-2,3… CONTINUE READING
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