Prominin-1: a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells.

@article{Corbeil2010Prominin1AD,
  title={Prominin-1: a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells.},
  author={Denis Corbeil and Anne-Marie Marzesco and Christine A. Fargeas and Wieland B Huttner},
  journal={Sub-cellular biochemistry},
  year={2010},
  volume={51},
  pages={
          399-423
        }
}
The apical plasma membrane of polarized epithelial cells is composed of distinct subdomains, that is, planar regions and protrusions (microvilli, primary cilium), each of which are constructed from specific membrane microdomains. Assemblies containing the pentaspan glycoprotein prominin-1 and certain membrane lipids, notably cholesterol, are characteristic features of these microdomains in apical membrane protrusions. Here we highlight the recent findings concerning the molecular architecture… CONTINUE READING
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