Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients.

@article{Rajkowska2005ProminentRI,
  title={Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients.},
  author={Grażyna Rajkowska and Jos{\'e} Javier Miguel-Hidalgo and Priti Dubey and Craig A Stockmeier and K. Ranga R. Krishnan},
  journal={Biological psychiatry},
  year={2005},
  volume={58 4},
  pages={297-306}
}
BACKGROUND Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined. METHODS Postmortem samples from the orbitofrontal cortex (ORB) were collected in 15 elderly subjects with major depressive disorder (MDD) and 11 age-matched control subjects. Cell packing density of neurons and glia, density of pyramidal and… CONTINUE READING

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