Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.

@article{Fahy1995ProminentNI,
  title={Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation.},
  author={John V Fahy and Kyung Won Kim and Jun Tao Liu and H. A. Jr. Boushey},
  journal={The Journal of allergy and clinical immunology},
  year={1995},
  volume={95 4},
  pages={
          843-52
        }
}
To infer possible mechanisms of acute airway inflammation and mucus hypersecretion in acute severe asthma, we performed cellular and biochemical analysis on sputum from 18 adults with acute severe asthma and compared the results with results of analysis of sputum from 12 adults with cystic fibrosis (CF). We found that in subjects with asthma neutrophils made up more than 75% of sputum cells in 10 samples whereas eosinophils made up more than 75% of cells in only three samples. Fifty percent of… CONTINUE READING
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