Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.

@article{Tesseur2000ProminentAA,
  title={Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.},
  author={I Tesseur and Jo Van Dorpe and K Bruynseels and Francisca C. Bronfman and Rafa{\"e}l Sciot and Alfons Van Lommel and Fred van Leuven},
  journal={The American journal of pathology},
  year={2000},
  volume={157 5},
  pages={1495-510}
}
The epsilon 4 allele of the human apolipoprotein E gene (ApoE4) constitutes an important genetic risk factor for Alzheimer's disease. Recent experimental evidence suggests that human ApoE is expressed in neurons, in addition to being synthesized in glial cells. Moreover, brain regions in which neurons express ApoE seem to be most vulnerable to neurofibrillary pathology. The hypothesis that the expression pattern of human ApoE might be important for the pathogenesis of Alzheimer's disease was… CONTINUE READING

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