Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus

@inproceedings{Sugiyama2014ProminentSW,
  title={Prominent Steatosis with Hypermetabolism of the Cell Line Permissive for Years of Infection with Hepatitis C Virus},
  author={Kazuo Sugiyama and Hirotoshi Ebinuma and Nobuhiro Nakamoto and Noriko Sakasegawa and Yuko Murakami and Po-Sung Chu and Shingo Usui and Yuka Ishibashi and Yuko Wakayama and Nobuhito Taniki and Hiroko Murata and Yoshimasa Saito and Masayoshi Fukasawa and Kyoko Saito and Yoshiyuki Yamagishi and Takaji Wakita and Hiroshi Takaku and Toshifumi Hibi and Hidetsugu Saito and T. Hosokawa Kanai},
  booktitle={PloS one},
  year={2014}
}
Most of experiments for HCV infection have been done using lytic infection systems, in which HCV-infected cells inevitably die. Here, to elucidate metabolic alteration in HCV-infected cells in a more stable condition, we established an HCV-persistently-infected cell line, designated as HPI cells. This cell line has displayed prominent steatosis and supported HCV infection for more than 2 years, which is the longest ever reported. It enabled us to analyze metabolism in the HCV-infected cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Long-term follow-up of hepatitis C infection in a large cohort of patients with inherited bleeding disorders

  • DEFvd Putte, M Makris, K Fischer, TT Yee, L Kirk
  • Journal of Hepatology
  • 2013
1 Excerpt

Similar Papers

Loading similar papers…