Prominent 5–18 Hz oscillations in the pallidal-thalamic circuit in secondary dystonia

@article{Tsang2012Prominent5H,
  title={Prominent 5–18 Hz oscillations in the pallidal-thalamic circuit in secondary dystonia},
  author={Eric W. Tsang and Clement Hamani and Elena Moro and Filomena Mazzella and A. M. Lozano and I J Yeh and R. Chen},
  journal={Neurology},
  year={2012},
  volume={78},
  pages={361 - 363}
}
Previous studies in primary dystonia suggested that abnormal oscillations of 5–18 Hz in the bilateral internal globus pallidus (GPi) may be a specific feature of dystonia.1–3 Moreover, voluntary movements were associated with bilateral desynchronization of β (<30 Hz) and contralateral synchronization of γ (∼70 Hz) frequencies in the GPi.2–4 We recorded local field potentials (LFPs) from the GPi and motor thalamus in a patient with severe hemidystonia to test the following hypotheses. First, the… 

Figures from this paper

The reorganization of motor network in hemidystonia from the perspective of deep brain stimulation
TLDR
Arguments for case-by-case assessment of DBS surgery indication and target selection in hemidystonia are provided and single-lead approach might be unable to modulate a highly disorganized network activity in certain patients with this clinical syndrome.
Toward adaptive deep brain stimulation for dystonia.
TLDR
The authors summarize the scientific research to date on pathological oscillations in dystonia and address potential biomarkers that might be used as a feedback signal for controlling aDBS in patients with Dystonia.
Unilateral thalamic and pallidal deep brain stimulation for idiopathic hemidystonia: results of individual and combined stimulations. Case report.
TLDR
The authors present the case of a 37-year-old woman who had suffered from idiopathic hemidystonia with hyperkinetic and hypokinetic movements for 11 years, and who was treated with deep brain stimulation, which resulted in a complete improvement of the mixed dystonic symptoms.
Frequency matters: beta‐band subthalamic nucleus deep‐brain stimulation induces Parkinsonian‐like blink abnormalities in normal rats
TLDR
Without destroying dopamine neurons or blocking dopamine receptors, frequency‐specific STN DBS can be used to create PD‐like or dystonic‐like symptoms in a normal rat.
Motor cortical circuits in Parkinson disease and dystonia.
Exploring the connections between basal ganglia and cortex revealed by transcranial magnetic stimulation, evoked potential and deep brain stimulation in dystonia.
Neural oscillation, network, eloquent cortex and epileptogenic zone revealed by magnetoencephalography and awake craniotomy
TLDR
The early experience using MEG in neurosurgical patients is described, emphasizing on its impact on patient management as well as the enrichment of knowledge in neurosciences.
...
...

References

SHOWING 1-7 OF 7 REFERENCES
The sensory and motor representation of synchronized oscillations in the globus pallidus in patients with primary dystonia.
TLDR
In 15 patients with primary dystonia who were treated with bilateral chronic pallidal stimulation, the sensorimotor modulation of the oscillatory local field potentials (LFPs) recorded from the pallidal electrodes were investigated and correlated with the surface electromyograms in the affected muscles.
Movement‐related synchronization of gamma activity is lateralized in patients with dystonia
TLDR
The presence of a lateralized movement‐related increase in gamma activity in the BG of patients with dystonia, similar to that recorded in patients with treated PD, suggests that this may be a residual feature of normal BG function, and provides further support for functional distinctions between BG oscillatory activities of different frequency.
Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?
TLDR
It is shown that pallidal local field potential activity <or= 10 Hz is coherent with dystonic movements, and that although the coupling between GP and activity in the sternocleidomastoid muscle is bidirectional, the drive from GP to muscle significantly outweighs that from muscle to GP.
Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movements
TLDR
The 5–18 Hz coherence at the bilateral GPi may be related to dystonia and its attenuation may facilitate voluntary movements, and the beta and gamma frequency bands in the GPi are modulated by the preparation of self-initiated movements and the execution of externally triggered movements.
The Physiological Effects of Pallidal Deep Brain Stimulation in Dystonia
TLDR
Physiological and imaging studies in dystonia patients with GPi DBS suggest that deep brain stimulation (DBS) of globus pallidus internus (GPi) acts primarily by major modification of basal ganglia output to brainstem, thalamus, and cortex resulting in neural reorganization, which may explain the characteristic progressive improvement in dySTONia after GPu DBS.
Carpenter's Human Neuroanatomy
A completely revised and updated text, retaining the morphological approach of previous editions, but with additional material on neuroscience, new information on the distribution of
Carpenter’s Human Neuroanatomy, 9th ed
  • Neurology
  • 1996