Promethazine affects autonomic cardiovascular mechanisms minimally.

  title={Promethazine affects autonomic cardiovascular mechanisms minimally.},
  author={Troy Brown and Dwain L Eckberg},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={282 2},
Promethazine hydrochloride, Phenergan, is a phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. These properties have made promethazine a candidate for use in environments such as microgravity, which provoke emesis and motion sickness. Recently, we evaluated carotid baroreceptor-cardiac reflex responses during two Space Shuttle missions 18 to 20 hr after the 50 mg intramuscular administration of promethazine. Because the… CONTINUE READING