Corpus ID: 45710682

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.

@article{Flp1998ProlylOA,
  title={Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.},
  author={V. F{\"u}l{\"o}p and Z. B{\"o}cskei and L. Polgár},
  journal={Cell},
  year={1998},
  volume={94 2},
  pages={
          161-70
        }
}
Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an alpha/beta hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual beta propeller. This domain makes… Expand
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