Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

  title={Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression},
  author={Giulia Franciosa and G Diluvio and Francesca Del Gaudio and Maria Valeria Giuli and Rocco Palermo and Paola Grazioli and Antonio Francesco Campese and Claudio Talora and Diana Bellavia and Giulia d'Amati and Zein Mersini Besharat and Carmine Nicoletti and Christian W Siebel and Lisa Choy and Alessandra Rustighi and Giannino Del Sal and Isabella Screpanti and Saula Checquolo},
Deregulated Notch signaling is associated with T-cell Acute Lymphoblastic Leukemia (T-ALL) development and progression. Increasing evidence reveals that Notch pathway has an important role in the invasion ability of tumor cells, including leukemia, although the underlying molecular mechanisms remain mostly unclear. Here, we show that Notch3 is a novel target protein of the prolyl-isomerase Pin1, which is able to regulate Notch3 protein processing and to stabilize the cleaved product, leading to… CONTINUE READING
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