Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.

  title={Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins.},
  author={Yih-Cherng Liou and Xiao Zhen Zhou and Kun Lu},
  journal={Trends in biochemical sciences},
  volume={36 10},
Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes. Such conformational changes represent a novel and tightly controlled signaling mechanism regulating a spectrum of protein activities in physiology and disease; often through phosphorylation-dependent, ubiquitin-mediated proteasomal degradation. In this review, we summarize recent advances in elucidating the role and regulation of Pin1 in… CONTINUE READING
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