Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium.

@article{Wang2011ProlylHA,
  title={Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium.},
  author={Zhuo A Wang and Divyendu Singh and H. van der Wel and C. West},
  journal={Developmental biology},
  year={2011},
  volume={349 2},
  pages={
          283-95
        }
}
O(2) regulates multicellular development of the social amoeba Dictyostelium, suggesting it may serve as an important cue in its native soil environment. Dictyostelium expresses an HIFα-type prolyl 4-hydroxylase (P4H1) whose levels affect the O(2)-threshold for culmination implicating it as a direct O(2)-sensor, as in animals. But Dictyostelium lacks HIFα, a mediator of animal prolyl 4-hydroxylase signaling, and P4H1 can hydroxylate Pro143 of Skp1, a subunit of E3(SCF)ubiquitin-ligases. Skp1… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
A cytoplasmic prolyl hydroxylation and glycosylation pathway modifies Skp1 and regulates O2-dependent development in Dictyostelium.
Role of a Cytoplasmic Dual-function Glycosyltransferase in O2 Regulation of Development in Dictyostelium*
Prolyl 4-hydroxylase-1 mediates O2 signaling during development of Dictyostelium
The Skp1 Prolyl Hydroxylase from Dictyostelium Is Related to the Hypoxia-inducible Factor-α Class of Animal Prolyl 4-Hydroxylases*
Analysis of Skp1 glycosylation and nuclear enrichment in Dictyostelium.
Molecular Characterization of a Novel UDP-galactose:Fucoside α3-Galactosyltransferase That Modifies Skp1 in the Cytoplasm of Dictyostelium*
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